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Accumulation of visceral fat in maintenance hemodialysis patients

Takatomi Yurugi1, Satoshi Morimoto, Takayuki Okamoto

  • 1Second Department of Internal Medicine, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan. yurugitakatomi@yahoo.co.jp

Clinical and Experimental Nephrology
|October 13, 2011
PubMed

Insights

Visceral obesity is more common than high BMI or abnormal lipids in hemodialysis patients. High visceral fat, especially with diabetes, is linked to arterial stiffness and atherosclerosis.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Obesity and lipid abnormalities are significant risk factors for cardiovascular disease and mortality in hemodialysis (HD) patients.
  • Visceral obesity, specifically, is a critical concern in this population.

Purpose of the Study:

  • To compare the incidence of abnormal lipid profiles and visceral obesity in patients undergoing maintenance HD.
  • To investigate the relationship between visceral fat area (VFA) and markers of arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and atherosis (carotid intima-media thickness, IMT).

Main Methods:

  • Computed tomography scans were used to determine visceral obesity.
  • Incidences of abnormal lipid profiles and VFA were compared in maintenance HD patients.
  • The correlation between VFA, baPWV, and carotid IMT was analyzed, particularly in patients with and without diabetes mellitus (DM).

Main Results:

  • The incidence of high VFA (27.0%) was substantially higher than high BMI (9.7%), high LDL-C (4.8%), or high triglycerides (12.7%).
  • In diabetic patients, waist circumference and VFA positively correlated with baPWV.
  • Patients with high VFA and DM exhibited significantly higher baPWV and carotid IMT compared to other groups.

Conclusions:

  • High visceral fat accumulation is more prevalent than other obesity or lipid markers in hemodialysis patients.
  • Visceral fat is associated with increased arterial stiffness and atherosis, particularly in diabetic patients on maintenance HD.
Abstract

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