Related Experiment Video
Updated: May 28, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Phenols with anti-HIV activity from Daphne acutiloba
Sheng Zhuo Huang1, Xing Jie Zhang, Xing Yao Li
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Abstract:
The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively.
Related Concept Videos
Antiviral Nucleoside Inhibitors
Antiprotozoal Agents
Antifungal Agents
Antimicrobial Effectiveness
Inhibitors Of Virion Release
