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Related Experiment Video

Updated: May 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Sacral neuromodulation for lower urinary tract dysfunction.

Philip E V Van Kerrebroeck¹, Tom A T Marcelissen

¹Department of Urology, Maastricht University Medical Center, Maastricht, The Netherlands. p.vankerrebroeck@mumc.nl

World Journal of Urology

|October 13, 2011

Summary

This summary is machine-generated.

Sacral neuromodulation (SNM) offers a safe and effective treatment for lower urinary tract dysfunction, including urgency and incontinence. This minimally invasive technique is recommended after conservative therapies fail.

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Last Updated: May 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

Urology
Neurology
Medical Devices

Background:

Lower urinary tract dysfunction (LUTD) affects a significant patient population.
Current treatments for LUTD have limitations and varying success rates.

Purpose of the Study:

To review the technique, indications, results, and mechanisms of sacral neuromodulation (SNM).
To evaluate SNM as a therapeutic option for lower urinary tract dysfunction.

Main Methods:

Literature search on sacral neuromodulation for LUTD.
Discussion based on available literature and clinical experience.

Main Results:

SNM involves stimulating the 3rd sacral nerve via an implanted electrode and pulse generator.
FDA-approved since 1997, SNM has treated ~26,000 patients with urgency, frequency, incontinence, and retention.
Effective in ~70% of patients, SNM also shows promise for pelvic pain.
It modulates central nervous system micturition reflexes.

Conclusions:

Sacral neuromodulation is a safe and effective therapy for various LUTD.
It is indicated for urgency, frequency, urgency incontinence, and non-obstructive urinary retention.
SNM should be considered the primary option after maximal conservative therapy failure.