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Possible mechanism of antidepressant effect of L-sulpiride
G Serra1, A Forgione, P S D'Aquila
1B. B. Brodie Department of Neurosciences, University of Cagliari, Italy.
Clinical Neuropharmacology
|January 1, 1990
Abstract:
L-Sulpiride is a dopamine (DA)-receptor blocker that acts as an antidepressant at low doses. We have reviewed evidence suggesting that the antidepressant effect of L-sulpiride may depend on the activation of DA transmission secondary to the blockade of DA autoreceptors.