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Updated: May 28, 2026

An Aptamer-based Sensor for Unchelated Gadolinium(III)
Published on: January 9, 2017
The use of gadolinium chelates as an alternative radiographic contrast agent for use with flat panel detector
Ferdinand K Hui1, Frank C Tong, Jacques E Dion
1Cleveland Clinic, Cerebrovascular Center, Cleveland, Ohio, USA. huif@ccf.org
Abstract:
Gadolinium chelates can be utilized as a fluoroscopic contrast agent when iodinated contrast is contraindicated. However, the nephrotoxicity of gadolinium at radiographic doses limits its role as fluoroscopic contrast. Gadolinium chelate-enhanced digital subtraction angiography (DSA) is particularly limited by the kV of DSA, where gadolinium chelates are relatively more radiolucent. Flat panel detectors improve conspicuity of gadolinium chelates during DSA and should be employed where possible.
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