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05:57

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Published on: July 2, 2013

The antipseudomonal property of honey and gentamicin

O E Adeleke1, P B Olaitan

  • 1Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria.

Annals of Burns and Fire Disasters
|October 13, 2011
PubMed

Insights

This study found that honey effectively combats antibiotic-resistant Pseudomonas aeruginosa. All tested honey samples demonstrated 100% sensitivity against this resistant bacterium, offering a natural alternative.

Area of Science:

  • Microbiology
  • Natural Products Research
  • Antimicrobial Resistance

Background:

  • Pseudomonas aeruginosa exhibits significant resistance to conventional antimicrobial agents.
  • This resistance poses a major challenge in clinical settings.
  • Investigating natural alternatives is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the antimicrobial activity of honey against clinical isolates of Pseudomonas aeruginosa.
  • To compare the efficacy of honey with a standard antibiotic, gentamicin.
  • To determine if honey can overcome the widespread antibiotic resistance of P. aeruginosa.

Main Methods:

  • Agar-cup diffusion method was employed for sensitivity testing.
  • Fifty human isolates of Pseudomonas aeruginosa from various pathological sources were used.
  • Tests were conducted using undiluted honey from three sources and gentamicin at 8 and 4 µg/ml.

Main Results:

  • All 50 P. aeruginosa isolates showed 100% sensitivity to undiluted honey.
  • Gentamicin exhibited variable antipseudomonal activity at tested concentrations.
  • Diluted honey (1:2) showed less inhibition compared to undiluted honey and gentamicin.

Conclusions:

  • Honey demonstrates potent antimicrobial activity against Pseudomonas aeruginosa.
  • Undiluted honey is effective in overcoming antibiotic resistance in P. aeruginosa.
  • Honey presents a promising natural therapeutic option for treating P. aeruginosa infections.
Keywords:
antipseudomonalgentamicinhoneyproperty

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