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Related Experiment Video

Updated: May 28, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Burn scar neoplasm.

A R Kadir1

  • 1Division of Plastic, Reconstruction and Cosmetic Surgery, Department of Surgery, College of Medicine, University of Sulaimani, Sulaimani, Iraq.

Annals of Burns and Fire Disasters
|October 13, 2011
PubMed
Summary
This summary is machine-generated.

Marjolin's ulcer, a rare skin cancer developing in burn scars, frequently affects the scalp and lower limbs. This study found a high recurrence rate and mortality following treatment, highlighting the aggressive nature of this malignancy.

Keywords:
BURNNEOPLASMSCAR

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Marjolin's ulcer is a rare, aggressive cutaneous malignancy.
  • It typically arises in skin with a history of trauma or chronic inflammation, particularly burn scars.
  • Untreated or ungrafted burn injuries have a higher incidence of developing this carcinoma.

Purpose of the Study:

  • To analyze the clinical characteristics, treatment outcomes, and recurrence patterns of Marjolin's ulcer.
  • To evaluate the efficacy of different treatment modalities for this condition.

Main Methods:

  • A prospective review of medical records for 48 patients diagnosed with Marjolin's ulcer between 2000 and 2006.
  • Histological examination to confirm diagnosis as well-differentiated squamous cell carcinoma.
  • Analysis of treatment interventions including excision, grafting, flaps, amputation, and chemotherapy.

Main Results:

  • The mean age at diagnosis was 40 years, with a 2:1 male to female ratio.
  • The scalp (33.3%) and lower limb (29.1%) were the most commonly affected sites.
  • Local recurrence was observed in 33.3% of patients, all of whom died from the recurrence.

Conclusions:

  • Marjolin's ulcer is an aggressive malignancy with a high rate of local recurrence and mortality.
  • Early diagnosis and effective treatment strategies are crucial, though challenging.
  • The study underscores the severe prognosis associated with Marjolin's ulcer, particularly following recurrence.