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Related Concept Videos

The Availability Heuristic01:08

The Availability Heuristic

A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):

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Related Experiment Video

Updated: May 28, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

S Siah1, A Baite, H Bakkali

  • 1Service de chirurgie plastique et des brûlés.

Annals of Burns and Fire Disasters
|October 13, 2011
PubMed
Summary

Lyell syndrome, or toxic epidermal necrolysis (TEN), is a severe drug-induced skin reaction. Early, multidisciplinary intensive care is crucial for managing TEN, focusing on supportive care and infection control.

Area of Science:

  • Dermatology
  • Toxicology
  • Intensive Care Medicine

Context:

  • Lyell syndrome (toxic epidermal necrolysis, TEN) is a severe, life-threatening mucocutaneous blistering disease.
  • It is primarily triggered by medications and characterized by acute epidermal necrosis.
  • Clinical presentation mimics extensive deep second-degree burns, often with mucosal involvement and multi-visceral complications.

Purpose:

  • To highlight the critical importance of early and multidisciplinary management of TEN patients.
  • To emphasize the role of specialized burn intensive care units in managing TEN.
  • To discuss the foundational elements of TEN care, including asepsis, fluid resuscitation, nutrition, infection prevention/treatment, and local wound care.

Summary:

  • Two cases of TEN illustrate the necessity of prompt, comprehensive care in a burn intensive care setting.

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  • Management principles include strict asepsis, optimal hydro-electrolytic and nutritional support, infection prophylaxis and treatment, and meticulous nursing and local care.
  • The efficacy of intravenous immunoglobulins remains uncertain due to limited evidence from isolated cases and lack of randomized trials.

    • Impact:

    • Early and specialized intensive care significantly impacts TEN patient outcomes.
    • This multidisciplinary approach, centered in a burn unit, provides a framework for managing this severe dermatological emergency.
    • Further research is needed to validate novel treatments like intravenous immunoglobulins for TEN.