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Fibroblast growth factor. Chemical structure and biologic function.

D Gospodarowicz¹

¹Cancer Research Institute, University of California, San Francisco 94143.

Clinical Orthopaedics and Related Research

|August 1, 1990

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Basic and acidic fibroblast growth factors (FGF) are crucial morphogens and mitogens affecting numerous tissues. Basic FGF also induces mesoderm formation, explaining its wide developmental roles from embryo to adult.

Area of Science:

Developmental Biology
Cell Biology
Oncogenes

Background:

Basic and acidic fibroblast growth factors (FGF) share a receptor and similar biological effects.
FGFs are structurally related to oncogenes implicated in various cancers.
The precise physiological functions of FGFs are not fully understood.

Purpose of the Study:

To elucidate the roles of basic and acidic FGF in physiological processes.
To understand the broader impact of FGF signaling in development and disease.

Main Methods:

Comparative analysis of basic and acidic FGF functions.
Investigating FGFs' roles as morphogens and mitogens.
Examining FGFs' effects on mesoderm and neuroectoderm differentiation.

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Main Results:

Both FGF types act as morphogens and mitogens on diverse cell types.
Basic FGF induces mesoderm formation from animal pole cells at the midblastula stage.
FGF signaling impacts the central nervous system, peripheral nervous system, and vascular system throughout development.

Conclusions:

FGFs play a fundamental role in embryonic development, influencing cell fate and tissue formation.
Basic FGF's role as a ventrovegetalizing factor is critical for mesoderm induction.
FGF signaling is vital for the development and maintenance of multiple organ systems.