Related Experiment Video
Updated: May 28, 2026
08:49
Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Ondansetron and meperidine prevent postoperative shivering after general anesthesia
Masoud Entezari Asl1, Khatereh Isazadefar, Ali Mohammadian
1Ardebil University of Medical Sciences, Iran.
Middle East Journal of Anaesthesiology
|October 14, 2011
Summary
Ondansetron effectively prevents postoperative shivering after general anesthesia, significantly reducing its incidence compared to Meperidine and placebo. This finding offers a valuable option for managing this common complication.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Postoperative shivering is a frequent complication of general anesthesia.
- It can lead to various adverse outcomes.
- Preventive strategies are crucial for patient recovery.
Purpose of the Study:
- To evaluate the efficacy of Ondansetron in preventing postoperative shivering.
- To compare Ondansetron with Meperidine and placebo for shivering prevention.
Main Methods:
- A randomized, placebo-controlled, double-blind clinical trial was conducted.
- 90 patients undergoing elective gynecologic surgery were divided into three groups.
- Ondansetron, Meperidine, or placebo was administered before anesthesia induction.
Main Results:
- Ondansetron reduced shivering incidence to 13.3%, Meperidine to 20%, compared to 50% in the control group.
- Temperature changes, blood pressure, and heart rate variations were similar across groups.
- Nausea incidence was comparable; vomiting was lower with Ondansetron.
Conclusions:
- Ondansetron demonstrates significant effectiveness in reducing postoperative shivering.
- It presents a viable prophylactic option for managing shivering post-anesthesia.
Related Concept Videos
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
01:24General Anesthesia: Overview
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
01:24Parenteral Anesthetics: Overview
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
01:31Skeletal Muscle Relaxants: Therapeutic Uses
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
01:27Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
Although all competitive neuromuscular blockers are designed...