Basal ganglia calcification with hypoparathyroidism: a case report

Zelealem Assfaw1, Getachew Assefa

  • 1Department of Radiology, Addis Ababa University, Medical Faculty, Addis Ababa, Ethiopia.

Ethiopian Medical Journal
|October 14, 2011
PubMed

Insights

Basal ganglia calcification typically occurs after age forty. This case report details a seventeen-year-old boy with pathological basal ganglia calcification linked to hypoparathyroidism.

Area of Science:

  • Neurology
  • Endocrinology
  • Radiology

Background:

  • Basal ganglia calcification (BGC) is uncommon in individuals under forty.
  • Pathological causes should be suspected for early-onset BGC.
  • Idiopathic BGC is rare, necessitating investigation into underlying conditions.

Observation:

  • A seventeen-year-old male presented with symptoms suggestive of basal ganglia calcification.
  • Radiological imaging confirmed calcification within the basal ganglia.
  • Endocrine evaluation revealed coexisting hypoparathyroidism.

Findings:

  • The patient exhibited pathological basal ganglia calcification at a young age.
  • Hypoparathyroidism was identified as a potential contributing factor to the calcification.
  • This association highlights a rare presentation of BGC.

Implications:

  • Early-onset BGC in adolescents warrants thorough investigation for metabolic and endocrine disorders.
  • Hypoparathyroidism should be considered in the differential diagnosis of pathological BGC.
  • This case expands the understanding of BGC etiology and its association with endocrine dysfunction.

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...