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Updated: May 28, 2026
03:19
Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
Published on: June 21, 2024
Renal parenchymal volume increases after contralateral nephrectomy: assessment using three-dimensional
Yasuhito Funahashi1, Ryohei Hattori, Tokunori Yamamoto
1Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan. funa418@yahoo.co.jp
Summary
Following unilateral nephrectomy, remaining kidney volume increases acutely due to blood flow changes, impacting long-term renal function. Kidney volume changes predict future kidney function recovery.
Area of Science:
- Nephrology
- Surgical Research
- Medical Imaging
Background:
- Unilateral nephrectomy necessitates compensatory mechanisms in the remaining kidney.
- Understanding the dynamics of renal parenchymal volume (RPV) changes post-nephrectomy is crucial for predicting renal function.
- Previous studies have not fully elucidated the temporal relationship between RPV changes and functional recovery.
Purpose of the Study:
- To investigate the relationship between changes in renal parenchymal volume (RPV) and renal function after unilateral nephrectomy.
- To assess the impact of acute and chronic RPV changes on single-kidney glomerular filtration rate (GFR).
Main Methods:
- Prospective study including 46 patients undergoing unilateral nephrectomy.
- Three-dimensional ultrasonography used for serial RPV measurements (pre-surgery, and at 4.3h, 2 days, 7 days post-surgery).
- Multivariate regression analysis to correlate RPV with single-kidney GFR and body surface area.
Main Results:
- RPV significantly increased within hours of surgery and remained elevated at 7 days post-surgery.
- RPV was positively associated with single-kidney GFR and body surface area.
- Patients with <5% RPV increase at 1 week showed no significant GFR increase at 2 years, unlike others.
Conclusions:
- Acute kidney volume expansion post-nephrectomy is likely driven by hemodynamic changes and increased renal blood flow.
- Chronic phase may involve histological hypertrophic responses contributing to sustained RPV.
- Early RPV changes are a significant predictor of long-term single-kidney GFR recovery after unilateral nephrectomy.
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