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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...

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Biodegradable thermogels.

Min Hee Park1, Min Kyung Joo, Bo Gyu Choi

  • 1Department of Bioinspired Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Korea.

Accounts of Chemical Research
|October 14, 2011
PubMed
Summary
This summary is machine-generated.

Biodegradable thermogels, particularly polypeptide-based materials, offer controlled drug delivery and cell scaffolding. Researchers manipulated polymer properties for tailored biomedical applications, demonstrating long-term insulin delivery and cartilage tissue engineering.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Stimuli-responsive polymers change conformation with external triggers like temperature.
  • Thermogel polymers transition from solution to gel with increasing temperature, enabling in situ hydrogel formation.
  • These hydrogels serve as depots for drug delivery or matrices for cell growth.

Purpose of the Study:

  • To describe key materials for biodegradable thermogels, focusing on polypeptide-based systems.
  • To provide insights into controlling thermogel properties like transition temperature and degradability for biomedical applications.
  • To explore the role of secondary structure and nanoassembly in polypeptide thermogels.

Main Methods:

  • Synthesized biodegradable thermogels using various hydrophobic (e.g., PLA-GA, PCL, polypeptides) and hydrophilic (e.g., PEG, PVP) blocks.
  • Modified polypeptides by varying stereochemistry, molecular weight, composition, end-capping, and microsequences to control thermosensitivity and nanoassembly.
  • Introduced pH-sensitive groups for dual temperature and pH responsiveness.

Main Results:

  • Developed polypeptide-based thermogels where secondary structure and nanoassembly dictate material properties.
  • Demonstrated control over sol-gel transition temperature, gel modulus, critical gel concentration, and degradability.
  • Polypeptide copolymers showed stability in buffer but accelerated degradation with proteolytic enzymes.

Conclusions:

  • Biodegradable thermogels, especially polypeptide-based ones, offer tunable properties for biomedical applications.
  • Demonstrated successful in vivo hypoglycemic efficacy for over 16 days with insulin-loaded thermogels in diabetic rats.
  • Thermogel scaffolds supported chondrocyte growth and extracellular matrix production, and facilitated in situ cell imaging.