Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The blood-brain interface.

M W Bradbury1, S L Lightman

  • 1Department of Physiology, King's College London.

Eye (London, England)
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

The brain

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The blood-brain barrier in vitro.

Neurochemistry international·2010
Same author

Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets.

International journal of obesity (2005)·2008
Same author

Hypothalamic and amygdaloid corticotropin-releasing hormone (CRH) and CRH receptor-1 mRNA expression in the stress-hyporesponsive late pregnant and early lactating rat.

Brain research. Molecular brain research·2001
Same author

ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guérin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

CRH in chronic inflammatory stress.

Peptides·2001
Same author

Interphotoreceptor retinoid binding protein peptide-induced uveitis in B10.RIII mice: characterization of disease parameters and immunomodulation.

Experimental eye research·2001
Same journal

Eyelid margin tick masquerading as a naevus in a child.

Eye (London, England)·2026
Same journal

Full-thickness macular penetration by welding laser injury.

Eye (London, England)·2026
Same journal

Incidence and characteristics of newly formed polypoidal lesions in polypoidal choroidal vasculopathy.

Eye (London, England)·2026
Same journal

Traumatic intravitreal egg-shaped hematoma.

Eye (London, England)·2026
Same journal

Rare ocular triad: Goldenhar syndrome with Duane retraction syndrome and optic disc pit.

Eye (London, England)·2026
Same journal

AS-OCT demonstration of anterior capsular delamination in unilateral true exfoliation.

Eye (London, England)·2026
See all related articles

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Ophthalmology

Background:

  • The blood-brain barrier (BBB) is formed by brain capillary endothelium, distinct from peripheral capillaries.
  • Key features include tight junctions, high electrical resistance, low polar solute permeability, and specialized transport mechanisms.
  • The retinal barrier shares similarities but also involves the pigment epithelium, separating it from the choroid.

Purpose of the Study:

  • To delineate the unique properties of the blood-brain barrier and retinal barrier.
  • To explore functional differences, particularly concerning diabetic damage resistance.
  • To hypothesize potential mechanisms for the observed differences in diabetic resistance.

Main Methods:

  • Comparative analysis of cerebral and retinal capillary endothelium properties.

Related Experiment Videos

  • Examination of transport mechanisms, ion pumps, and mitochondrial density.
  • Assessment of microvessel resistance to diabetic damage.

    • Main Results:

    • Cerebral microvessels exhibit greater resistance to diabetic damage compared to retinal microvessels.
    • The BBB is characterized by tight junctions, high electrical resistance, and specialized transport.
    • Retinal barrier function is influenced by both capillary endothelium and pigment epithelium.

    Conclusions:

    • The blood-brain barrier possesses unique structural and functional characteristics.
    • Cerebral microvessels show enhanced resilience against diabetic injury.
    • Differences in interstitial fluid glucose regulation may explain varying diabetic resistance.