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Recent advancements in multimodality treatment of gliomas
Mersiha Hadziahmetovic1, Katsuyuki Shirai, Arnab Chakravarti
1Department of Radiation Oncology, Arthur G James Comprehensive Cancer Center & Richard L Solove Research Institute, The Ohio State University Medical Center, Columbus, 43210, USA.
Abstract:
Gliomas account for the vast majority of malignant adult brain tumors. Even though tremendous effort has been made to optimize treatment of patients with high-grade glioma, the prognosis remains poor, especially for patients with glioblastoma. The dismal prognosis conferred by these tumors is in part caused by the tendency to diffusely infiltrate into neighboring brain tissue, but also by the inherent resistance of these tumors to both chemotherapy and radiation. This article reviews the recent advancements in multimodality treatment of patients with gliomas, both in the primary and recurrent setting, with an emphasis on the emerging targeted therapies. Moreover, the external beam radiotherapy options, including intensity modulated radiotherapy and particle (proton and carbon ion) radiotherapy are reviewed.
Insights
This review covers advanced treatments for malignant adult brain tumors (gliomas), focusing on improving outcomes for high-grade glioma and glioblastoma patients. It highlights new targeted therapies and radiotherapy techniques.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Medical Oncology
Background:
- Gliomas represent the majority of malignant adult brain tumors.
- High-grade gliomas, particularly glioblastoma, have a poor prognosis due to diffuse infiltration and resistance to conventional therapies.
- Despite efforts, treatment optimization for gliomas remains a significant challenge.
Purpose of the Study:
- To review recent advancements in the multimodality treatment of gliomas.
- To emphasize emerging targeted therapies for primary and recurrent gliomas.
- To discuss current and novel external beam radiotherapy options.
Main Methods:
- Literature review of recent advancements in glioma treatment.
- Focus on targeted therapies and their application.
- Review of external beam radiotherapy techniques, including intensity modulated radiotherapy and particle therapy.
Main Results:
- Recent advancements offer new hope for glioma patients.
- Targeted therapies are emerging as a promising addition to standard treatment protocols.
- Advanced radiotherapy techniques like intensity modulated radiotherapy and particle therapy are expanding treatment options.
Conclusions:
- Multimodality treatment, incorporating targeted therapies and advanced radiotherapy, is crucial for improving glioma patient outcomes.
- Further research into novel therapeutic strategies is essential.
- Personalized treatment approaches are key to addressing the challenges posed by gliomas.
