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Recommendations for probiotic use-2011 update.
Martin H Floch1, W Allan Walker, Karen Madsen
1Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06150, USA. martin.floch@yale.edu
Journal of Clinical Gastroenterology
|October 14, 2011
Summary
This Yale Workshop updates probiotic use recommendations, covering microbiota, immunologic responses, and conditions like diarrhea and inflammatory bowel disease. Fecal microbiome transplants are recommended for severe Clostridium difficile infections.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The third Yale Workshop convened 10 experts to update probiotic use recommendations from 2005 and 2008.
- Discussions focused on the role of normal microbiota in intestinal microecology and immune system interactions.
- Key areas included probiotic organism stability, natural history, and impact on obesity and cardiac risk factors.
Framework:
- Recommendations for probiotic use in specific conditions were reviewed and updated.
- A, B, or C ratings were assigned to probiotic recommendations.
- The workshop addressed the use of probiotics in necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile diarrhea.
Implementation:
- The consensus opinion of workshop participants guides the updated recommendations.
- Presentations and papers from the workshop supplement the consensus findings.
- Expert consensus forms the basis for rating probiotic efficacy and application.
Implications:
- Updated guidelines provide evidence-based recommendations for clinical probiotic use.
- The study highlights the evolving understanding of the gut microbiome's influence on health.
- Positive recommendations for fecal microbiome transplants in refractory Clostridium difficile infections are included.
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