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Updated: May 28, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
HBV-Specific Adaptive Immunity
Antonio Bertoletti1,2,3, Anthony T Tan1, Adam J Gehring1
1Laboratory of Hepatic Viral Diseases, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*Star), 30 Medical Drive, 117609, Singapore.
Abstract:
The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in patients with resolved or chronic HBV infection and analyze how the liver environment can directly modulate HBV-immunity.
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