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Updated: May 28, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Hepatitis C virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress
Sophie Clément1, Stéphanie Pascarella1, Francesco Negro1,2
1Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.
Abstract:
The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The objective of this review is to discuss three of these cofactors: steatosis, insulin resistance and oxidative stress. Although all may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. This review summarizes the current understanding and potential molecular pathways by which HCV contributes to their development.
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