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Related Experiment Video

Updated: May 28, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Bunyaviruses and the type I interferon system.

Richard M Elliott¹, Friedemann Weber

¹Centre for Biomolecular Sciences, School of Biology, University of St. Andrews, St. Andrews, KY16 9ST, Scotland, UK;

|October 14, 2011

Summary

This summary is machine-generated.

Bunyaviruses are a global threat transmitted by arthropods. This review details how these viruses overcome the host interferon system to establish infection, despite limited knowledge of their virulence mechanisms.

Keywords:

NSs proteins bunyaviruses interferon system

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Last Updated: May 28, 2026

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Published on: March 24, 2015

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Area of Science:

Virology
Immunology
Pathogen Biology

Background:

The family Bunyaviridae comprises over 350 viruses globally distributed.
Many bunyaviruses are arthropod-borne and cause significant diseases in humans, animals, and plants.
Bunyaviruses represent an emerging threat, yet their virulence mechanisms remain poorly understood.

Purpose of the Study:

To summarize current knowledge on bunyavirus virulence.
To elucidate how bunyaviruses establish infection despite the host's interferon response.

Main Methods:

Review of existing scientific literature on bunyavirus-host interactions.
Analysis of studies detailing bunyavirus evasion of interferon-mediated antiviral immunity.

Main Results:

Bunyaviruses employ diverse strategies to counteract the interferon system.
Specific viral proteins and their roles in inhibiting interferon signaling pathways are highlighted.

Conclusions:

Understanding bunyavirus virulence mechanisms is crucial for controlling emerging viral diseases.
Further research into bunyavirus-interferon interactions will inform therapeutic strategies.