Related Experiment Video
Updated: May 28, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
Published on: November 12, 2015
Making of viral replication organelles by remodeling interior membranes
Zsuzsanna Sasvari1, Peter D Nagy
1Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA;
Abstract:
Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.
Related Concept Videos
Retrovirus Life Cycles
Intralumenal Vesicles and Multivesicular Bodies
Vesicular Tubular Clusters
With the help of motor proteins such...
Viral Recombination
Intracellular Movement of Viruses and Bacteria
Viral Structure

