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Updated: May 28, 2026

Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes
Published on: February 22, 2017
How HIV takes advantage of the cytoskeleton in entry and replication
Bettina Stolp1, Oliver T Fackler
1Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany. bettina.stolp@med.uni-heidelberg.de
Abstract:
The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.
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