Related Experiment Video
Updated: May 28, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction
Anna Le Tortorec1, Suzanne Willey, Stuart J D Neil
1Department of Infectious Disease, King's College London School of Medicine, Guy's Hospital, London SE19RT, UK.
Abstract:
Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.
More Related Videos
Related Concept Videos
Inhibitors Of Virion Release
Inhibitors of Virion Maturation and Assembly
Antiviral Nucleoside Inhibitors
Inhibitors of Viral Protein Synthesis
Subviral Agents
Viruses with RNA Genomes

