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Updated: May 28, 2026
08:36
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
Dengue--quo tu et quo vadis?
1Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. ruchen@utmb.edu
Viruses
|October 14, 2011
Summary
Dengue viruses (DENV) are a major global health threat. This review explores DENV evolution, including genetic changes and population dynamics, to understand transmission and disease emergence.
Area of Science:
- Virology
- Evolutionary Biology
- Epidemiology
Background:
- Dengue viruses (DENV) are significant arboviral pathogens globally.
- They belong to the Flavivirus genus, with four distinct serotypes (DENV-1-4).
- Nearly one-third of the world's population is at risk of DENV infection.
Purpose of the Study:
- To review the current understanding of Dengue virus evolution.
- To analyze factors influencing DENV transmission, pathogenesis, and emergence.
Main Methods:
- Phylogenetic analyses of DENV genetic data.
- Examination of evolutionary rates, selection pressures, population sizes, and constraints.
Main Results:
- Phylogenetic analyses provide insights into DENV origins and evolution.
- Understanding evolutionary forces is crucial for predicting DENV spread and impact.
Conclusions:
- DENV evolution is shaped by various factors including rates of change and population dynamics.
- Knowledge of DENV evolution aids in managing transmission and preventing disease emergence.
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