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Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

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Published on: September 19, 2013

Unconventional use of LC3 by coronaviruses through the alleged subversion of the ERAD tuning pathway

Fulvio Reggiori1, Cornelis A M de Haan, Maurizio Molinari

  • 1Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. F.Reggiori@umcutrecht.nl

Viruses
|October 14, 2011
PubMed

Insights

Coronaviruses hijack endoplasmic reticulum pathways to replicate within host cells. Understanding these viral hijacking mechanisms is key to developing new antiviral therapies.

Area of Science:

  • Molecular biology
  • Virology
  • Cell biology

Background:

  • Pathogens, including viruses, exploit host cell machinery for survival and replication.
  • Understanding pathogen subversion mechanisms is vital for therapeutic target identification.
  • Coronaviruses are a significant public health concern, necessitating research into their replication strategies.

Purpose of the Study:

  • To review recent findings on coronavirus replication mechanisms.
  • To investigate how coronaviruses co-opt host cell pathways, specifically the endoplasmic reticulum.
  • To present models of potential coronavirus hijacking strategies for therapeutic development.

Main Methods:

  • Review of recent scientific literature and data on coronavirus-host interactions.
  • Analysis of molecular mechanisms involved in endoplasmic reticulum protein processing.
  • Development of theoretical models for viral hijacking of cellular components.

Main Results:

  • Evidence suggests coronaviruses utilize membranous carriers from the endoplasmic reticulum for replication.
  • These carriers contain proteins involved in the disposal of misfolded polypeptides.
  • Potential mechanisms for coronavirus hijacking of these endoplasmic reticulum-derived carriers are proposed.

Conclusions:

  • Coronaviruses likely exploit the endoplasmic reticulum's protein quality control system for their own propagation.
  • Detailed molecular characterization of these hijacking events can reveal novel therapeutic targets.
  • Further research into these mechanisms is crucial for combating coronavirus infections.
Keywords:
EDEM1EDEMosomesER quality controlERADMHVOS-9SARS-coronavirusautophagycoronavirusesdouble-membrane vesiclesnidoviruses

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