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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

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Updated: May 28, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Liver cancer stem cells.

Sameh Mikhail1, Aiwu Ruth He

  • 1Lombardi Comprehensive Cancer Center, Georgetown University Hospital, 3800 Reservoir Road Northwest, Washington, DC 20007, USA.

International Journal of Hepatology
|October 14, 2011
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) is a major liver cancer. Research indicates HCC originates from adult stem cells, and targeting these cancer stem cells may offer a cure.

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Area of Science:

  • Hepatology and Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent liver malignancy, ranking as the fifth most common solid cancer globally and the third leading cause of cancer mortality.
  • Emerging evidence suggests that liver cancer arises from adult stem cells, with potential involvement of at least three distinct progenitor cell lineages susceptible to neoplastic transformation.
  • Advancements in identifying cell surface markers, developing monoclonal antibodies, and employing cell sorting techniques have significantly enhanced the characterization of normal and potentially cancerous stem cells.

Purpose of the Study:

  • To explore the role of adult stem cells in the development of hepatocellular carcinoma (HCC).
  • To investigate the potential of targeting liver cancer stem cells as a therapeutic strategy for HCC.

Main Methods:

  • Review of experimental hepatocarcinogenesis models to identify progenitor cell lineages.
  • Utilizing cell surface markers, monoclonal antibodies, and cell sorting for stem cell characterization.
  • Analysis of signaling transduction pathways implicated in stem cell regulation during hepatocarcinogenesis.

Main Results:

  • Identification of multiple progenitor cell lineages with neoplastic potential in liver cancer models.
  • Demonstration of deregulated signaling pathways crucial for stem cell proliferation and differentiation in hepatocarcinogenesis.
  • Advancements in techniques for identifying and characterizing liver cancer stem cells.

Conclusions:

  • Hepatocellular carcinoma (HCC) is fundamentally a disease of adult stem cells.
  • Targeting liver cancer stem cells presents a promising therapeutic avenue for the potential cure of HCC.