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Related Experiment Video

Updated: May 28, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Axon diameter mapping in crossing fibers with diffusion MRI.

Hui Zhang1, Tim B Dyrby, Daniel C Alexander

  • 1Microstructure Imaging Group, Department of Computer Science, University College London, London WC1E 6BT, United Kingdom.

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
|October 15, 2011
PubMed
Summary

This study introduces a new diffusion MRI method to map axon diameter in complex brain regions with crossing fibers. This technique overcomes limitations of existing methods, enabling more precise microstructural analysis in diverse white matter areas.

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Area of Science:

  • Neuroimaging
  • Biomarkers
  • Diffusion MRI

Background:

  • Existing axon diameter mapping techniques in diffusion MRI are limited by the single fiber orientation assumption.
  • This limitation restricts their application to areas with highly coherent white matter, failing in complex fiber configurations.
  • Fiber crossings are prevalent in the brain, necessitating advanced methods for accurate microstructural analysis.

Purpose of the Study:

  • To develop and validate a novel diffusion MRI technique for mapping axon diameter in regions with crossing fibers.
  • To overcome the limitations of existing methods that assume a single fiber orientation.

Main Methods:

  • Proposed a novel crossing fiber tissue model for axon diameter mapping.
  • Validated the technique using diffusion MRI data.

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Last Updated: May 28, 2026

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  • Employed simulations to assess performance in two-fiber crossings.
  • Utilized ex vivo imaging data for feasibility demonstration.

    • Main Results:

    • The proposed technique demonstrated robust axon diameter estimation in simulated two-fiber crossings (down to 45 degrees).
    • Feasibility was confirmed using ex vivo data, yielding reasonable axon diameter indices in a complex crossing region.
    • The method enables axon diameter mapping in voxels containing multiple fiber populations.

    Conclusions:

    • The novel crossing fiber model enables accurate axon diameter mapping in complex white matter regions.
    • This advancement offers a new class of specific biomarkers for tissue microstructure analysis using diffusion MRI.
    • The technique expands the applicability of diffusion MRI for detailed brain white matter investigation.