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Three-Dimensional Shape Modeling and Analysis of Brain Structures
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Vertex-wise shape analysis of the hippocampus: disentangling positional differences from volume changes.

Hosung Kim1, Tommaso Mansi, Andrea Bernasconi

  • 1Department of Neurology and McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. khs001@bic.mni.mcgill.ca

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
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Summary

Hippocampal atrophy and positional changes often occur together in neurological disorders. This study introduces a new surface-based method to analyze both volume and position independently, revealing co-occurrence in epilepsy patients.

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Area of Science:

  • Neuroimaging
  • Computational Anatomy
  • Medical Image Analysis

Background:

  • Hippocampal atrophy and positional variations are observed in neurological conditions.
  • Existing methods may not fully disentangle volume and positional changes.
  • A novel analytical framework is needed to address these co-occurring phenomena.

Purpose of the Study:

  • To develop and validate a surface-based framework for independent analysis of hippocampal volume and position.
  • To investigate the co-occurrence of atrophy and positional variants in neurological disorders, specifically temporal lobe epilepsy.
  • To localize and characterize these changes within the hippocampus.

Main Methods:

  • Utilized spherical harmonics combined with point distribution models (SPHARM-PDM) for surface extraction.
  • Computed displacement vectors and surface-based Jacobian determinants (SJD) to quantify volume changes.
  • Developed a mean meridian axis (MEMAX) for analyzing local curvatures and positional variants.

Main Results:

  • The proposed framework successfully validated on synthetic data and a large cohort of healthy subjects and epilepsy patients.
  • Demonstrated co-occurrence of atrophy and positional changes in the posterior hippocampus of epilepsy patients.
  • SPHARM-PDM indicated mirrored deformations, SJD detected atrophy, and MEMAX analysis revealed medial positioning due to bending.

Conclusions:

  • The developed surface-based framework enables independent assessment of hippocampal volume and position.
  • Confirms the co-occurrence of hippocampal atrophy and medial positional shifts in temporal lobe epilepsy.
  • Provides a more nuanced understanding of structural brain changes in neurological disorders.