Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Reactions

Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Upper Respiratory Drugs: First and Second-Generation Antihistamines

Upper Respiratory Drugs: First and Second-Generation Antihistamines

Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Chronic Angioedema Registry (CARE): Rationale, Methods and Implementation.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2024

Same author

Allergens Responsible for Anaphylaxis After Olive Fruit Ingestion.

Journal of investigational allergology & clinical immunology·2023

Same author

Subcutaneous C1 Inhibitor for Long-term Prophylaxis of Hereditary Angioedema: A Real-life Experience.

Journal of investigational allergology & clinical immunology·2023

Same author

Cluster Subanalysis of Patients With Severe Asthma Who Responded to Omalizumab.

Journal of investigational allergology & clinical immunology·2021

Same author

The Importance of Small Airway Dysfunction in Asthma: The GEMA-FORUM III Task Force.

Journal of investigational allergology & clinical immunology·2021

Same author

Achievement of effective cardiopulmonary trauma surgical skills training throughout the incorporation of a low-cost and easy to implement pulsatile simulation model.

Injury·2021

Search research articles

Related Experiment Video

Updated: May 28, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

NSAID-sensitive antihistamine-induced urticaria/angioedema.

S Cimbollek¹, M Ortega Camarero, R Avila

¹Allergy Department, Hospital Virgen del Rocío, Seville, Spain. scimbollek@gmail.com

Journal of Investigational Allergology & Clinical Immunology

|October 15, 2011

Summary

This study details a rare case of antihistamine-induced urticaria in a patient with nonsteroidal anti-inflammatory drug (NSAID) sensitivity. Researchers identified a specific subset of antihistamine urticaria linked to NSAID sensitivity.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Related Experiment Videos

Last Updated: May 28, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Allergy and Immunology
Pharmacology
Dermatology

Background:

Nonsteroidal anti-inflammatory drug (NSAID) sensitivity can manifest as hypersensitivity reactions.
Urticaria and angioedema are common allergic reactions, but drug-induced cases require careful diagnosis.

Observation:

A patient with NSAID sensitivity experienced immediate generalized urticaria with ibuprofen and naproxen.
Delayed urticarial reactions were noted after previous oral antihistamine use.
Skin tests for loratadine and cetirizine were negative, but oral challenge with loratadine induced urticaria.

Findings:

The patient developed urticaria and angioedema after a placebo-controlled oral challenge with piroxicam.
A subsequent oral challenge with loratadine resulted in generalized urticaria.
Fexofenadine was tolerated, suggesting specific antihistamine sensitivities.

Implications:

This case suggests a potential new subset of antihistamine-induced urticaria.
The condition is termed NSAID-sensitive antihistamine-induced urticaria/angioedema.
Further research is needed to understand the mechanisms and prevalence of this specific drug hypersensitivity.