Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metal-Semiconductor Junctions

Metal-Semiconductor Junctions

The contact of metal and semiconductor can lead to the formation of a junction with either Schottky or Ohmic behavior.
Schottky Barriers
Schottky barriers arise when a metal with a work function (Φm) contacts a semiconductor with a different work function (Φs). Initially, electrons transfer until the Fermi levels of the metal and semiconductor align at equilibrium. For instance, if Φm > Φs, the semiconductor Fermi level is higher than the metal's before contact. The semiconductor's...

Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

Assembly of Signaling Complexes

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Control of Electron Transfer Kinetics at Glassy Carbon Electrodes by Specific Surface Modification.

Analytical chemistry·2026

Same author

Photocurrent Experiments as Probes and Prods in Large-Area Molecular Electronic Junctions.

Journal of the American Chemical Society·2025

Same author

A practical approach to estimate analytical method variability from routine testing.

Journal of pharmaceutical and biomedical analysis·2024

Same author

Carbon-Based Molecular Junctions for Practical Molecular Electronics.

Accounts of chemical research·2022

Same author

Evaluation of Carbon Based Molecular Junctions as Practical Photosensors.

ACS sensors·2020

Same author

Comment on "Extent of conjugation in diazonium-derived layers in molecular junction devices determined by experiment and modelling" by C. Van Dyck, A. J. Bergren, V. Mukundan, J. A. Fereiro and G. A. DiLabio, <i>Phys. Chem. Chem. Phys.</i>, 2019, <b>21</b>, 16762.

Physical chemistry chemical physics : PCCP·2020

Search research articles

Related Experiment Video

Updated: May 28, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Assembling molecular electronic junctions one molecule at a time.

Andrew P Bonifas¹, Richard L McCreery

¹Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, Ohio 43210, United States.

|October 15, 2011

Summary

Surface-mediated metal deposition (SDMD) allows for precise measurement of single-molecule conductance by minimizing heat and structural disruption. This technique enables quantitative comparisons across molecular junctions of varying sizes.

More Related Videos

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

Published on: January 11, 2012

Related Experiment Videos

Last Updated: May 28, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

Published on: January 11, 2012

Area of Science:

Molecular electronics
Surface science
Nanotechnology

Background:

Establishing electronic contact to molecules is crucial for molecular electronics.
Traditional methods often involve significant heat or structural disturbance.
A gentle method is needed to probe single-molecule properties.

Purpose of the Study:

To introduce and validate Surface-Mediated Metal Deposition (SDMD) as a soft technique for creating molecular junctions.
To measure the conductance of single and few-molecule junctions.
To compare molecular conductance across different molecular lengths and types.

Main Methods:

Utilizing surface-mediated metal deposition (SDMD) for controlled metal atom diffusion onto molecular monolayers.
Measuring electrical current through the molecular layer during metal deposition.
Analyzing conductance steps corresponding to molecule "recruitment" as contact area grows.
Obtaining current-voltage characteristics for single and few-molecule junctions.

Main Results:

SDMD enabled observation of molecular conductance for junctions with as few as one molecule.
Discrete conductance steps indicated the "recruitment" of 1-10 molecules.
Alkane monolayer conductance showed exponential dependence on length (β = 0.90 per CH(2)).
Azobenzene molecule conductance correlated with HOMO-Fermi level offset.
Current-voltage curves remained consistent from single to multiple molecules, suggesting minimal interaction.

Conclusions:

SDMD is a "soft" deposition method suitable for single-molecule conductance measurements.
The technique allows for quantitative comparisons between single-molecule and large-scale molecular junctions.
SDMD provides insights into charge transport mechanisms in molecular systems.