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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated

S L D'Ascia1, C D'Ascia, V Marino

  • 1Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

International Journal of Clinical Practice
|October 15, 2011
PubMed

Insights

Cardiac resynchronization therapy (CRT) may prevent new-onset atrial fibrillation (AF) in patients with non-ischaemic dilated cardiomyopathy. Non-responders to CRT showed a significantly higher incidence of AF over three years.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Non-ischaemic idiopathic-dilated cardiomyopathy is a significant cause of severe heart failure.
  • Atrial fibrillation (AF) is a common complication in heart failure patients.
  • Cardiac resynchronization therapy (CRT) is a treatment option for selected heart failure patients.

Purpose of the Study:

  • To evaluate the effect of CRT on the incidence of new-onset AF.
  • To assess long-term AF development in responders versus non-responders to CRT.
  • To investigate CRT's role in preventing AF in a specific heart failure population.

Main Methods:

  • Prospective, single-centre study involving 58 AF-naïve patients receiving CRT.
  • Patients were categorized as responders (72.4%) or non-responders (27.6%) after 1 year.
  • AF incidence was compared between groups at 1, 2, and 3 years post-implantation.

Main Results:

  • Non-responders had a significantly higher incidence of new-onset AF at 1 year (18.2% vs. 3.3%, p < 0.05).
  • This difference persisted at 2 years (33.3% vs. 12.2%) and 3 years (50.0% vs. 15.0%).
  • Three-year follow-up showed non-responders had a 5.67-fold increased risk of developing new-onset AF.

Conclusions:

  • CRT may have a protective effect against new-onset AF in patients with non-ischaemic dilated cardiomyopathy.
  • Patient response to CRT is a critical factor in AF prevention.
  • This study highlights CRT's potential as a non-pharmacological strategy for AF prevention in this cohort.
Abstract

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