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Updated: May 28, 2026

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
Structural insights into regulation and action of SWI2/SNF2 ATPases
1TC Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218-2685, USA.
Abstract:
This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.
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