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Blood Transfusion

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Updated: May 28, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Pediatric transfusion practices: A single-center retrospective study].

C Navarro¹, E Ducher, H Tas

¹Service de pédiatrie, centre régional de cancérologie et thérapie cellulaire pédiatrique, hôpital Estaing, CHU de Clermont-Ferrand, Clermont-Ferrand, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|October 15, 2011

Summary

This summary is machine-generated.

Pediatric transfusion practices show significant deviation from national guidelines, particularly in red blood cell and platelet transfusions. Simplifying guidelines and exploring pathogen inactivation may improve adherence.

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Last Updated: May 28, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Pediatric Hematology
Transfusion Medicine
Clinical Practice Guidelines

Context:

Pediatric transfusions are critical for managing various conditions, including malignancies, intensive care, and surgical needs.
Assessing adherence to national transfusion guidelines in pediatric care is essential for patient safety and resource optimization.
University hospital centers play a key role in establishing and evaluating transfusion practices.

Purpose:

To describe professional practices in pediatric transfusion.
To evaluate the accuracy of current national transfusion guidelines in pediatric patients.
To identify discrepancies between recommended and actual transfusion protocols.

Summary:

A retrospective analysis of 1,607 pediatric transfusions (red cells, platelets, plasma) in a French university hospital revealed significant nonconformity with national guidelines (35.9% for red cells, 41.6% for platelets).
Oncohematology, intensive care, and surgery were the primary drivers for pediatric transfusions, with adverse events reported in 0.6% of cases.
Noncompliance was often linked to inappropriate irradiation and cytomegalovirus seronegative specifications, highlighting variability in risk assessment.

Impact:

Observed discrepancies underscore the need for clearer, more practical transfusion guidelines in pediatric settings.
The findings suggest that simplifying transfusion protocols and adopting advanced techniques like photochemical pathogen inactivation could enhance adherence and patient safety.
This study provides valuable data for refining pediatric transfusion strategies and improving the effective use of blood products.