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Updated: May 28, 2026
09:43
Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Glutathionyl hemoglobin is elevated in iron deficiency anemia
1Department of Medical Oncology, Division of Molecular Medicine, St. Johns National Academy of Health Sciences, Bangalore, India. arunshet@sjri.res.in
Acta Haematologica
|October 15, 2011
Summary
Glutathionyl hemoglobin (GSHb) is elevated in iron deficiency anemia (IDA) patients, showing potential as a novel biomarker for this condition. This finding offers new diagnostic possibilities for IDA.
Area of Science:
- Biochemistry
- Hematology
- Analytical Chemistry
Background:
- Iron deficiency anemia (IDA) lacks reliable biomarkers.
- IDA is associated with increased oxidative stress.
- Novel biomarkers are needed for accurate IDA diagnosis.
Purpose of the Study:
- To identify novel biomarkers for iron deficiency anemia (IDA).
- To investigate the role of oxidative stress in IDA pathogenesis.
- To evaluate glutathionyl hemoglobin (GSHb) as a potential IDA biomarker.
Main Methods:
- Utilized mass spectrometry (MS), including MALDI-MS and electrospray ionization MS.
- Identified specific oxidative modifications of hemoglobin.
- Quantified glutathionyl hemoglobin (GSHb) levels in IDA patients and controls.
Main Results:
- Elevated levels of glutathionyl hemoglobin (GSHb) were observed in IDA patients compared to controls (p = 0.002).
- GSHb levels showed inverse correlations with serum ferritin, hemoglobin, mean cell volume, serum iron, and transferrin saturation.
- GSHb levels demonstrated a positive correlation with serum transferrin receptor.
Conclusions:
- Glutathionyl hemoglobin (GSHb) is significantly elevated in patients with iron deficiency anemia (IDA).
- GSHb presents potential as a novel and reliable biomarker for diagnosing IDA.
- This study highlights the link between oxidative stress and IDA.
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