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Updated: May 28, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives
Mariano Walter Pertino1, Cristina Theoduloz, Jose Antonio Palenzuela
1Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
Abstract:
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
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