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07:54
Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Copper metabolism and pediatric cholestasis.
1Department of Pediatrics, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA. mrcorkin@pol.net
Current Opinion in Clinical Nutrition and Metabolic Care
|October 15, 2011
Summary
Copper is essential, and its levels are regulated by the body. Despite concerns, cholestasis in infants does not lead to elevated copper levels, necessitating careful monitoring during parenteral nutrition.
Area of Science:
- Biochemistry
- Clinical Nutrition
- Pediatrics
Background:
- Copper is a vital trace mineral, essential for numerous physiological processes.
- Copper homeostasis is primarily regulated by hepatic excretion through the biliary system.
- Clinical guidelines previously advised caution with copper administration in cholestatic patients receiving parenteral nutrition.
Purpose of the Study:
- To review the role of copper in human health and disease.
- To evaluate the impact of cholestasis on copper metabolism in patients receiving parenteral nutrition.
- To assess the necessity of copper supplementation in cholestatic infants on parenteral nutrition.
Main Methods:
- Review of recent clinical reports and scientific literature on copper metabolism and transport.
- Analysis of studies investigating copper levels in cholestatic patients, particularly infants, on parenteral nutrition.
- Evaluation of the consequences of copper deficiency and toxicity.
Main Results:
- Identification of key transporters involved in copper regulation and associated genetic disorders.
- Evidence suggests that cholestasis in infants does not invariably lead to elevated serum copper levels.
- Reports indicate a rise in copper deficiency cases among patients who had copper withheld due to cholestasis concerns.
Conclusions:
- Copper is essential, with levels dynamically regulated based on individual needs.
- Hepatic excretion is the main mechanism for copper regulation.
- Careful monitoring of copper levels is crucial for patients on parenteral nutrition, even in the presence of cholestasis, to prevent deficiency.
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