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Updated: May 28, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Optic neuropathy associated with CANOMAD: description of 2 cases
Lara Sanvito1, Yusuf A Rajabally
1Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, Leicester LES 4PW, UK.
Abstract:
CANOMAD is a chronic ataxic neuropathy associated with IgM paraproteinemia and reactivity against disialosyl gangliosides. Ophthalmoplegia is a typical feature, but optic pathway involvement has not been reported previously. We describe 2 cases of CANOMAD associated with optic neuropathy. Severe visual loss was present in 1 case. We postulate that optic nerve damage may be related to antibody reactivity against gangliosides. Our report broadens the spectrum of cranial nerve involvement in this rare entity.
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