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Updated: May 28, 2026

A Multimodal Wide-Field Fourier-Transform Raman Microscope
Published on: December 30, 2025
Novel Fourier-domain constraint for fast phase retrieval in coherent diffraction imaging
Tatiana Latychevskaia1, Jean-Nicolas Longchamp, Hans-Werner Fink
1Institute of Physics, University of Zurich, Winterthurerstrasse 190, CH-8057, Switzerland. tatiana@physik.uzh.ch
Coherent diffraction imaging (CDI) advances atomic resolution visualization of single molecules. A novel Fourier-domain constraint improves numerical phase retrieval, enabling faster and more reliable reconstructions.
Area of Science:
- Optics and Photonics
- Materials Science
- Computational Imaging
Background:
- Coherent diffraction imaging (CDI) is a powerful technique for atomic resolution imaging.
- A key challenge in CDI is the accurate numerical phase retrieval from diffraction patterns.
- Existing phase retrieval methods often rely on iterative procedures with object and detector plane constraints.
Purpose of the Study:
- To develop a novel numerical method for phase retrieval in CDI.
- To overcome the limitations of conventional phase retrieval techniques.
- To enhance the speed and reliability of iterative reconstruction processes in CDI.
Main Methods:
- Introduction of a novel Fourier-domain constraint for phase retrieval, inspired by holography.
- Iterative propagation of complex-valued wave between object and detector planes.
- Application of both object and Fourier-domain constraints during reconstruction.
Main Results:
- The proposed method achieves low-resolution reconstruction in the initial steps.
- High-resolution reconstruction is obtained after subsequent iterative steps.
- Demonstrated fast and reliable convergence compared to conventional CDI schemes.
Conclusions:
- The novel Fourier-domain constraint significantly improves CDI phase retrieval.
- This method offers a more efficient and robust approach for atomic resolution imaging.
- The technique holds promise for advancing single-molecule visualization and materials characterization.
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