Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lipid metabolism and aging].

M Matsumoto1, H Tatsumi, A Murai

  • 1Department of Geriatric Medicine, Kyoto University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 1, 1990
PubMed
Summary

Excess plasma lipids contribute to atherosclerosis risk. Age-related lipid changes, like decreased linoleic acid, pose cardiovascular risks, prompting research into dietary interventions for healthier lipid metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracellular interaction between FcRY receptor and IgY in ovarian vascular endothelial cells during avian maternal IgY transfer.

Poultry science·2025
Same author

Comprehensive analysis of gene expressions in ileal mucosa of chickens fed paddy rice and their IgA response to oral vaccination.

Poultry science·2025
Same author

Evaluation of a receptor gene responsible for maternal blood IgY transfer into egg yolks using bursectomized IgY-depleted chickens.

Poultry science·2020
Same author

Ingestion of paddy rice increases intestinal mucin secretion and goblet cell number and prevents dextran sodium sulfate-induced intestinal barrier defect in chickens.

Poultry science·2018
Same author

Outcome of fertility-sparing treatment with medroxyprogesterone acetate for atypical hyperplasia and endometrial carcinoma in young Japanese women.

European journal of gynaecological oncology·2014
Same author

Evaluation of primary prophylaxis with granulocyte colony-stimulating factor for epithelial ovarian cancer.

European journal of gynaecological oncology·2014

Area of Science:

  • Biochemistry
  • Gerontology
  • Nutritional Science

Context:

  • Elevated plasma lipids, particularly LDL cholesterol, are risk factors for atherosclerotic disease.
  • Age-related changes in lipid metabolism include increased LDL cholesterol and triglycerides, and decreased linoleic acid.
  • Low high-density lipoprotein (HDL) cholesterol levels remain a significant risk factor, even in the elderly.

Purpose:

  • To explore the impact of aging on lipid metabolism and its association with cardiovascular disease.
  • To investigate the role of dietary polyunsaturated fatty acids (PUFAs), specifically linoleic acid, in mitigating age-related lipid changes.
  • To determine if dietary interventions can counteract age-related lipid metabolism alterations and improve cellular function.

Summary:

  • Plasma lipid profiles change with age, increasing risks for atherosclerosis and cardiovascular events.
  • Decreased levels of serum linoleic acid with age represent an independent risk factor for cardiac and cerebral infarction.
  • Lipid peroxides, derived from PUFAs, may contribute to cellular aging and biomembrane damage.

Impact:

  • Understanding these age-related lipid changes is crucial for developing targeted nutritional strategies.
  • Dietary manipulation may offer a pathway to reduce cardiovascular disease risk in aging populations.
  • Further research is needed to confirm the efficacy of dietary interventions in improving lipid metabolism and cellular health in the elderly.

Related Experiment Videos