Related Experiment Video
Updated: May 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
The kidney and the elderly: why does the risk increase?
Pierangela Presta1, Gaetano Lucisano, Laura Fuiano
1Nephrology Unit, Magna Graecia University, Campus Germaneto, Viale Europa, 88100 Catanzaro, Italy.
Aging kidneys face increased risks from physiological changes and acquired factors like diseases and medications. Understanding these elements is crucial for preventing kidney damage in older adults.
Area of Science:
- Nephrology
- Geriatrics
- Internal Medicine
Background:
- Kidney function naturally declines with age, increasing susceptibility to renal diseases.
- This decline is influenced by unmodifiable physiological changes and modifiable pathological factors.
- The concept of
- .
- 2022-07-10T00:00:00Z
- Purpose_of_the_Study
- To review the factors contributing to renal damage in the elderly.
- To analyze physiological and pathological factors affecting kidney function in aging individuals.
- To highlight the increased risk of kidney damage in older populations due to specific conditions and medical interventions.
Purpose of the Study:
- To review the factors contributing to renal damage in the elderly.
- To analyze physiological and pathological factors affecting kidney function in aging individuals.
- To highlight the increased risk of kidney damage in older populations due to specific conditions and medical interventions.
Main Methods:
- Literature review of factors influencing renal function in aging.
- Analysis of physiological changes associated with senescence.
- Examination of acquired risk factors and their impact on kidney health.
Main Results:
- Aging involves physiological changes that decrease renal function.
- Acquired risk factors, such as age-related diseases and nephrotoxic drug use, increase kidney damage risk.
- Increased use of contrast media and major surgeries further elevate renal risk in the elderly.
Conclusions:
- Renal decline in aging is multifactorial, involving both physiological and pathological elements.
- Intervention targeting modifiable pathological factors can help prevent or mitigate kidney damage in older adults.
- A comprehensive understanding of these factors is essential for geriatric nephrology care.
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Chronic Kidney Disease I: Introduction
Bioavailability: Influencing Factors
