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Updated: May 28, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Accelerator-based stereotactic radiosurgery for brainstem metastases.

Chun-Shu Lin1, Michael T Selch, Steve P Lee

  • 1Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. chunshulin@gmail.com

Neurosurgery
|October 15, 2011
PubMed
Summary
This summary is machine-generated.

Linear accelerator-based stereotactic radiosurgery (linac-SRS) offers excellent local control for brainstem metastases, especially smaller tumors. This noninvasive treatment shows promise with manageable side effects for select patients.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Stereotactic radiosurgery (SRS) is a noninvasive treatment option for intracranial metastases.
  • Brainstem metastases present unique challenges due to the critical structures within the brainstem.

Purpose of the Study:

  • To evaluate the treatment outcomes of linear accelerator-based stereotactic radiosurgery (linac-SRS) specifically for brainstem metastases.
  • To assess local control rates, survival times, and complication risks associated with linac-SRS in this patient population.

Main Methods:

  • Retrospective review of a database of patients treated with linac-SRS for brainstem metastases between 1997 and 2008.
  • Analysis of patient demographics, tumor characteristics (volume), treatment parameters (dose, SRS mode), survival data, and complications.

Main Results:

  • Excellent local control rates of 92% at 6 months and 88% at 1 year were observed.
  • Median survival time was 11.6 months, with higher Karnofsky performance status correlating with longer survival.
  • Tumor volume (≤0.4 mL) and SRS mode (dynamic conformal arc) were significantly associated with improved local control.

Conclusions:

  • Linac-SRS provides excellent local control for brainstem metastases, particularly for tumors smaller than 0.4 mL, with relatively low serious morbidity.
  • A prescription dose of 14 Gy or higher is supported by the data for achieving high local control and low complication rates.
  • The study supports the use of linac-SRS as a viable treatment option for carefully selected patients with brainstem metastases.