Related Experiment Video
Updated: May 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Critical assessment of methods of protein structure prediction (CASP)--round IX
John Moult1, Krzysztof Fidelis, Andriy Kryshtafovych
1Institute for Bioscience and Biotechnology Research, and Department of Cell Biology and Molecular Genetics, University of Maryland, Rockville, MD 20850, USA. jmoult@umd.edu
Abstract:
This article is an introduction to the special issue of the journal PROTEINS, dedicated to the ninth Critical Assessment of Structure Prediction (CASP) experiment to assess the state of the art in protein structure modeling. The article describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Methods for modeling protein structure continue to advance, although at a more modest pace than in the early CASP experiments. CASP developments of note are indications of improvement in model accuracy for some classes of target, an improved ability to choose the most accurate of a set of generated models, and evidence of improvement in accuracy for short "new fold" models. In addition, a new analysis of regions of models not derivable from the most obvious template structure has revealed better performance than expected.
Related Concept Videos
Protein Organization
The primary structure of a protein is its amino acid sequence.
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...
Protein Folding
Protein Folding Quality Check in the RER
Protein and Protein Structures
A protein's shape is critical to its function. For example, an enzyme can...

