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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
What is the Immune System?01:38

What is the Immune System?

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Related Experiment Video

Updated: May 28, 2026

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Infectious diseases and autoimmunity.

Lucia Gemma Delogu1, Silvia Deidda, Giuseppe Delitala

  • 1Department of Drug Science, University of Sassari, Italy. lgdelogu@uniss.it

Journal of Infection in Developing Countries
|October 15, 2011
PubMed
Summary
This summary is machine-generated.

Infections from viruses and bacteria can trigger autoimmune diseases, even in genetically predisposed individuals. Pathogens initiate or worsen autoimmunity through mechanisms like molecular mimicry and adjuvant effects.

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Last Updated: May 28, 2026

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

  • Immunology
  • Pathogen-host interactions

Background:

  • Autoimmune diseases arise when the immune system attacks the body's own tissues.
  • Genetic factors and environmental triggers, especially infectious pathogens, are implicated in autoimmunity development.

Purpose of the Study:

  • To review the mechanisms by which infectious agents initiate or exacerbate autoimmunity.
  • To discuss evidence linking specific infections to human autoimmune diseases.
  • To describe animal models used in studying infection-autoimmunity links.

Main Methods:

  • Comprehensive literature search of PubMed, Cochrane, and Scopus databases.
  • No time limits were imposed on the search criteria.

Main Results:

  • Infectious agents can initiate or worsen autoimmunity through various pathways.
  • Evidence supports links between certain infections and human autoimmune conditions.
  • Relevant animal models are available for studying these connections.

Conclusions:

  • Viral and bacterial infections are key players in initiating and promoting autoimmune diseases, alongside genetic predisposition.
  • Pathogens can trigger autoimmunity via molecular mimicry and adjuvant effects.
  • Autoimmune responses are promoted by bystander activation or epitope spreading through inflammation and superantigens.