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Related Experiment Videos

LRC Coronary Prevention Trial: Baltimore.

G W Benedict

    Clinical Pharmacology and Therapeutics
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Recruiting for the Coronary Prevention Trial proved challenging. A community mass-screening approach was essential for success, significantly extending recruitment timelines and testing volume.

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    Area of Science:

    • Cardiovascular disease prevention research
    • Clinical trial recruitment strategies

    Background:

    • Enrollment for the Coronary Prevention Trial at Johns Hopkins University faced initial difficulties.
    • Referrals from private physicians and commercial laboratories were insufficient for meeting recruitment goals.

    Purpose of the Study:

    • To investigate the challenges and effectiveness of different recruitment strategies for a major cardiovascular prevention trial.
    • To identify optimal methods for identifying and enrolling participants in large-scale clinical studies.

    Main Methods:

    • Initial recruitment relied on physician and laboratory referrals.
    • A shift to a community-based mass-screening approach was implemented.
    • Extensive individual testing was conducted to identify eligible candidates.

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    Main Results:

    • Early recruitment efforts were largely unsuccessful, failing to meet enrollment targets.
    • The community mass-screening strategy proved effective in identifying sufficient study candidates.
    • Recruitment took 2.5 times longer than initially estimated, with 35,000 individuals tested.

    Conclusions:

    • Community mass-screening is a viable, albeit resource-intensive, strategy for recruiting participants in cardiovascular prevention trials.
    • Rethinking traditional referral-based recruitment is crucial for the success of large clinical studies.
    • Effective participant recruitment requires adaptive strategies and significant outreach efforts.