Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Antihypertensive Drugs: Potassium-Sparing Diuretics

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...

Mania and Antimanic Drugs: Overview

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...

Antihypertensive Drugs: Thiazide-Class Diuretics

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Urinary angiotensinogen as a novel mortality predictor in diabetic kidney disease: a propensity-matched analysis from the KNOW-CKD.

Clinical kidney journal·2026

Same author

Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Gout Risk: A Population-Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation.

Diabetes, obesity & metabolism·2026

Same author

Linking kidney impairment to amygdala volume changes and mental disorders: a Mendelian randomization study.

Kidney research and clinical practice·2026

Same author

Prognostic value of left atrial diameter in chronic kidney disease: The KNOW-CKD study.

Clinical medicine (London, England)·2026

Same author

Multiscale molecular modeling-directed ROS-responsive nanotherapy for dual-axis regulation of fibrotic and inflammatory signaling in alport nephropathy.

Journal of nanobiotechnology·2026

Same author

Hypocalcemia as a nontraditional risk factor for cardiovascular events and all-cause din patients with chronic kidney disease: insights from the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).

Kidney research and clinical practice·2026

Search research articles

Related Experiment Video

Updated: May 28, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Hyponatremia associated with bupropion.

Chang Seong Kim¹, Joon Seok Choi, Eun Hui Bae

¹Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Electrolyte & Blood Pressure : E & BP

|October 15, 2011

Summary

This summary is machine-generated.

Bupropion, used for depression and smoking cessation, can cause severe hyponatremia. This case highlights a rare complication of bupropion treatment, emphasizing the need for monitoring electrolyte levels during therapy.

Keywords:

antipsychotic agents bupropion elderly hyponatremia

Related Experiment Videos

Last Updated: May 28, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Area of Science:

Neuroscience
Endocrinology
Pharmacology

Background:

Bupropion is a commonly prescribed medication for major depressive disorder and smoking cessation.
Hyponatremia, a condition of low sodium levels, is a known potential side effect of certain medications.
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) can lead to severe hyponatremia.

Observation:

A 60-year-old male patient developed severe hyponatremia.
The patient was undergoing treatment with bupropion for depressive disorder.
This adverse event occurred upon initiation of bupropion therapy.

Findings:

The severe hyponatremia was attributed to bupropion treatment.
This represents the first reported case of bupropion-induced hyponatremia in Korea.
The patient's condition suggests a potential link between bupropion and SIADH.

Implications:

Clinicians should be vigilant for hyponatremia in patients treated with bupropion.
Monitoring serum sodium levels may be crucial during bupropion therapy, especially in susceptible individuals.
This case expands the understanding of bupropion's potential adverse effects and highlights the importance of pharmacovigilance.