Related Experiment Video
Updated: May 28, 2026
In Vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus
Published on: July 6, 2022
Microglia in the normally aged hippocampus
1Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea.
Abstract:
The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morphological changes of the hippocampus have been closely related to microglial changes during normal aging with or without disease. Therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain.
Insights
Aging impairs the hippocampus, crucial for memory and navigation. This review examines how changes in microglia, the brain's immune cells, relate to these age-related hippocampal declines.
Area of Science:
- Neuroscience
- Aging Research
- Immunology
Background:
- The hippocampus is vital for memory and spatial navigation.
- Aging leads to hippocampus functional decline and increased susceptibility to degenerative diseases.
- Microglia are the primary immune cells in the central nervous system, responding to brain changes.
Purpose of the Study:
- To review the morphological and functional changes in the hippocampus during aging.
- To examine the role and changes of microglia in the aging brain.
- To explore the relationship between hippocampal and microglial alterations in aging.
Main Methods:
- Literature review of studies on aging, hippocampus, and microglia.
- Analysis of morphological and functional changes in both hippocampus and microglia.
- Correlation of age-related changes between the hippocampus and microglia.
Main Results:
- Aging is associated with functional and structural decline in the hippocampus.
- Microglia exhibit significant morphological and functional alterations in the aged brain.
- Hippocampal changes during aging are closely linked to microglial activation and changes.
Conclusions:
- Microglial changes are integral to the aging process within the hippocampus.
- Understanding the hippocampus-microglia interaction is key to addressing age-related cognitive decline.
- Further research into microglial modulation may offer therapeutic strategies for aging brains.
More Related Videos
09:12Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
Published on: January 30, 2014
10:40Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
Published on: October 27, 2019