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Related Experiment Video

Updated: May 28, 2026

In Vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus

In Vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus

Published on: July 6, 2022

Microglia in the normally aged hippocampus.

Jung Hoon Choi¹, Moo-Ho Won

¹Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea.

Laboratory Animal Research

|October 15, 2011

Summary

This summary is machine-generated.

Aging impairs the hippocampus, crucial for memory and navigation. This review examines how changes in microglia, the brain's immune cells, relate to these age-related hippocampal declines.

Keywords:

Aging brain immune cells memory

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Published on: October 27, 2019

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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

Area of Science:

Neuroscience
Aging Research
Immunology

Background:

The hippocampus is vital for memory and spatial navigation.
Aging leads to hippocampus functional decline and increased susceptibility to degenerative diseases.
Microglia are the primary immune cells in the central nervous system, responding to brain changes.

Purpose of the Study:

To review the morphological and functional changes in the hippocampus during aging.
To examine the role and changes of microglia in the aging brain.
To explore the relationship between hippocampal and microglial alterations in aging.

Main Methods:

Literature review of studies on aging, hippocampus, and microglia.
Analysis of morphological and functional changes in both hippocampus and microglia.
Correlation of age-related changes between the hippocampus and microglia.

Main Results:

Aging is associated with functional and structural decline in the hippocampus.
Microglia exhibit significant morphological and functional alterations in the aged brain.
Hippocampal changes during aging are closely linked to microglial activation and changes.

Conclusions:

Microglial changes are integral to the aging process within the hippocampus.
Understanding the hippocampus-microglia interaction is key to addressing age-related cognitive decline.
Further research into microglial modulation may offer therapeutic strategies for aging brains.