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Updated: May 28, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Sirtuins: multifaceted drug targets.
S P Chakrabarty1, H Balaram, S Chandrasekaran
1Aurigene Discovery Technologies Ltd, Electronic City, Bangalore 560100, India.
Sirtuin proteins (Sir2) regulate key cellular processes like aging and cancer. Researchers use genetics and medicinal chemistry to discover Sir2 modulators for pharmacological and chemical genetic studies.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Sirtuin (Sir2) proteins are crucial regulators of cellular processes.
- Sir2s are implicated in aging, cancer, and neurological disorders.
Purpose of the Study:
- To investigate the diverse functions of Sirtuin proteins.
- To explore the pharmacological potential of Sir2 modulators.
Main Methods:
- Genetic studies
- Molecular biology techniques
- Biochemical assays
- Structural biology
- Medicinal chemistry approaches
Main Results:
- Significant insights into diverse Sir2 functions have been gained.
- Small molecule activators and inhibitors of Sir2 have been discovered.
Conclusions:
- Sir2 modulators have pharmacological significance.
- Chemical genetics can be used to understand Sir2's role in cellular processes.
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