Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2015
Same author

What is the point of large-scale collections of human induced pluripotent stem cells?

Nature biotechnology·2013
Same author

Pharma's developing interest in stem cells.

Cell stem cell·2010
Same author

An audience with Ruth McKernan.

Nature reviews. Drug discovery·2009
Same author

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2003

Related Experiment Video

Updated: May 28, 2026

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Regenerative medicine research at Pfizer. Interview with Ruth McKernan.

Ruth McKernan

    Regenerative Medicine
    |October 18, 2011
    PubMed
    Summary

    Pfizer

    Area of Science:

    • Regenerative Medicine
    • Neuroscience
    • Pharmaceutical Industry

    Background:

    • Pfizer's regenerative medicine research program was founded by Ruth McKernan.
    • McKernan is a distinguished neuroscientist and Chief Scientific Officer at Pfizer Neusentis.
    • She has a strong academic background with a PhD in pharmacology and extensive research experience.

    Discussion:

    • The article discusses the establishment and strategic direction of Pfizer's regenerative medicine initiatives.
    • It highlights the significance of this program as a major pharmaceutical industry entry into the field.
    • McKernan's leadership and vision are central to the program's development.

    Key Insights:

    • Pfizer's commitment to regenerative medicine research is a significant development in the field.

    More Related Videos

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
    10:28

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

    Published on: April 3, 2021

    Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
    11:57

    Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

    Published on: April 21, 2016

    Related Experiment Videos

    Last Updated: May 28, 2026

    Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
    07:45

    Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

    Published on: October 25, 2024

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
    10:28

    Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

    Published on: April 3, 2021

    Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
    11:57

    Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

    Published on: April 21, 2016

  • The restructure of the unit is expected to shape the future of regenerative medicine at Pfizer.
  • McKernan's expertise has been crucial in establishing and guiding this pioneering research program.

    • Outlook:

    • The future of regenerative medicine at Pfizer is poised for advancement following the unit's restructure.
    • This initiative signals a growing trend of major pharmaceutical companies investing in cutting-edge biological therapies.
    • Continued innovation in regenerative medicine holds promise for novel therapeutic approaches.