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Updated: May 28, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Which dressing do donor site wounds need?: study protocol for a randomized controlled trial.

Anne M Eskes1, Fleur E Brölmann, Louise A A Gerbens

  • 1Quality Assurance & Process Innovation, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Trials
|October 18, 2011
PubMed
Summary
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This randomized clinical trial compares six dressings for donor site wounds after skin grafting. The study aims to identify the most effective, satisfying, and cost-efficient dressing to improve patient care.

Area of Science:

  • Wound healing research
  • Clinical trial methodology
  • Dermatology and plastic surgery

Background:

  • Donor site wounds from split-skin grafting are common, with varied commercial dressing options available.
  • The optimal standard dressing for these wounds remains unclear, leading to inconsistent patient care.
  • This protocol outlines a clinical trial to evaluate different treatment strategies for donor site wounds.

Purpose of the Study:

  • To investigate the effectiveness of various dressings for donor site wounds.
  • To determine which dressing offers the best balance of healing, patient satisfaction, and cost-effectiveness.
  • To promote uniformity and enhance the quality of care for patients with donor site wounds.

Main Methods:

  • A 14-center, six-armed randomized clinical trial involving 300 adult patients.

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  • Patients received one of six dressings: hydrocolloid, alginate, film, hydrofiber, silicone, or paraffin gauze.
  • Primary outcomes included time to complete wound healing and pain scores; secondary outcomes assessed adverse effects, scarring, satisfaction, and costs.

    • Main Results:

    • Data on the comparative effectiveness of the six dressings are being collected.
    • The study is powered to detect a 25% difference in mean healing time.
    • Analysis will follow the intention-to-treat principle.

    Conclusions:

    • The study will provide comprehensive data on donor site wound treatment options.
    • Findings will guide the promotion of superior dressings to clinicians.
    • The trial aims to standardize and improve the quality of care for donor site wounds.