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Salmonella typhi infection complicated by rhabdomyolysis, pancreatitis and polyneuropathy

Medhat Ali1, Hosam Abdalla

  • 1Department of Internal Medicine and Nephrology, UAQ Hospital, UAE. medhatali10@hotmail.com

Arab Journal of Nephrology and Transplantation
|October 18, 2011
PubMed
Abstract

Insights

Severe Salmonella typhi infection can cause rhabdomyolysis and acute kidney injury. This case highlights the importance of considering systemic infections in patients with these complications.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Neurology

Background:

  • Typhoid fever, caused by Salmonella typhi, is a significant global health concern.
  • While typically presenting with gastrointestinal and febrile symptoms, Salmonella typhi can lead to severe systemic complications.
  • This case report focuses on an unusual presentation of Salmonella typhi infection.

Observation:

  • A 42-year-old male developed severe metabolic acidosis, acute kidney injury, and rhabdomyolysis following a trip to India.
  • Clinical manifestations included shortness of breath, body aches, abdominal pain, and thrombocytopenia.
  • Diagnosis was confirmed by elevated creatine phosphokinase, abnormal kidney function tests, and positive blood cultures for Salmonella typhi.

Findings:

  • The patient required hemodialysis for acute kidney injury and mechanical ventilation for broncho-pneumonia.
  • Treatment with imipenem-cilastin and ciprofloxacin was initiated, followed by ceftazidime.
  • Post-recovery, the patient exhibited a diffuse axonal sensorimotor polyneuropathy, which gradually improved.

Implications:

  • This case underscores that common pathogens like Salmonella typhi can manifest with rare and severe complications.
  • Rhabdomyolysis and acute kidney injury should prompt consideration of underlying systemic infections.
  • Recognizing these atypical presentations is crucial for timely diagnosis and management of typhoid fever and its sequelae.

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