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Related Experiment Video

Updated: May 28, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

The hippocampus is functionally connected to the striatum and orbitofrontal cortex during context dependent decision

Robert S Ross¹, Katherine R Sherrill, Chantal E Stern

¹Psychology Department, Boston University, Boston, MA 02215, USA. bross@bu.edu

|October 18, 2011

Summary

The hippocampus influences decision-making by predicting future possibilities. This brain region shows increased connectivity with striatal and prefrontal areas during context-dependent choices.

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Published on: October 21, 2021

Area of Science:

Neuroscience
Cognitive Science
Decision-Making Research

Background:

Human behavior relies on context and past experiences for appropriate decision-making.
Understanding the neural mechanisms underlying context-dependent choices is crucial.

Purpose of the Study:

To investigate hippocampal functional connectivity during decisions involving sequential representations.
To explore the role of the hippocampus in integrating contextual information for action selection.

Main Methods:

Functional connectivity analysis of the hippocampus during a sequential learning and decision-making task.
Comparison of brain activity between overlapping and non-overlapping sequence conditions.
Assessment of connectivity during both stimulus presentation and critical choice points.

Main Results:

Increased hippocampal connectivity with striatum and anterior cingulate cortex during overlapping sequence presentation.
Enhanced hippocampal connectivity with orbitofrontal cortex at the choice point in the overlapping condition.
Differential functional connectivity patterns observed between overlapping and non-overlapping conditions.

Conclusions:

The hippocampus plays a role in predicting future events to guide decision-making.
Hippocampal functional connectivity supports the evaluation of choice options by prefrontal and striatal regions.
These findings elucidate the neural basis of contextually guided behavior.